Protein Engineering · Boyue Zhang

Trimeric Redesign of a CAR-T Costimulatory Transmembrane Domain

Supervised by Dr. Emma Petley · PIs: Prof. Matt Call & A/Prof. Melissa Call

WEHI Call Lab 2026 Ongoing

Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.